[Shaun]

Wikipedia is your friend.

According to lead singer, pianist and songwriter Isaac Slade, the song was composed and influenced by his experience while working as a mentor at a camp for troubled teens:
“ One of the youngsters I was paired up with was a musician. Here I was, a protected suburbanite, and he was just 17 and had all these problems. And no one could write a manual on how to save him. ”

Slade claims that the song is about all of the people that tried to reach out to the boy but were unsuccessful. As Slade says in an interview, the boy's friends and family approached him by saying, "Quit taking drugs or I won't talk to you again," but all he needed was some support. The verses of the song describe an attempt by an adult to confront a troubled teen. In the chorus, the singer laments that he himself was unable to save a friend because he did not know how.

While this was the original intent of the song, the band has opened the song to interpretation. They created a website where fans were welcome to submit music videos they had made for the song. This arose from the response that Slade got from the song:[2]