I've been catching up on The 100 this week and Ricky Whittle is in it, who used to be Calvin in Hollyoaks, checked his IMDb and he is also in Mistresses. So that's two big American shows he has landed roles on now
Weirdly his love interest on Hollyoaks, Roxanne McKee, is one of the others I can think of. She was Doreah on the first two seasons of Game of Thrones, and her IMDb says she was in a Hercules movie earlier this year (not The Rock one), and done a few episodes of Dominion.
Another on Game of Thrones is Nathalie Emmanuel, who joined in Season 3 and will be around for a while. She was also in Hollyoaks.
Can't think of anyone from the other soaps really.. There was the guy that played Stacey's brother in Eastenders getting one of the lead roles in the Hobbit franchise, but he dropped out. Kind of strange that Hollyoaks seems to be the one that produces the best talent despite being the one that gets made fun of the most.
Anyone think of any others?