I dunno about this one, unless it's delivered with venom and genuine nastiness, is being called/or calling someone a "Karen" offensive? Or just a light hearted joke?
I've seen the memes online, and more than 50% of the time it's a male being called a Karen. South Park did it recently with The Streaming Wars with Randy Marsh. I know one person irl who i'd consider a Karen, he's always taking to twitter to moan and get very precious about mundane things, as if he's the only person in the world experiencing these "non issues"