[Smithy]

Scientists say they have found a way to disarm the AIDS virus in research that could lead to a vaccine. Researchers have discovered that if they eliminate a cholesterol membrane surrounding the virus, HIV cannot disrupt communication among disease-fighting cells and the immune system returns to normal.

Scientists have discovered that HIV needs cholesterol, which it picks up from the first immune cells it infects, to keep the virus' outer membrane fluid. That allows it to communicate with - and disrupt - the body's immune system.

The long-term effect of this disrupted communication is to destroy the body’s normal defense against the AIDS virus, which is responsible for 1.8 million deaths each year.

But researchers say they can prevent HIV from damaging the immune system, if they remove the cholesterol from the virus’ outer membrane.

David Graham is a molecular biologist at The Johns Hopkins University in Baltimore, Maryland.

“By stealing cholesterol from the envelope of the virus, we can neutralize the subversion," said Graham. "We’ve broken the code; we can shut down the type of interference that HIV is having on the immune system.”

The cholesterol used by HIV, Graham notes, is not the same cholesterol that circulates in blood and causes coronary artery disease. He says the AIDS virus incorporates cholesterol into its membrane from plasmacytoid dendritic cells or pDCs - the first immune cells to recognize the virus. The pDC cells normally signal the adaptive part of the immune system - T cells - to form a more specific, long-lasting response.

But through its newly-acquired cholesterol membrane, Graham says HIV reprograms the immune system - starting with the first responder cells - so they become hyperactive.

“These cells are just saying, 'No way. We’re not shutting off," he said. "We are going to keep responding.' And that causes the cells of the adaptive immune system to start shutting down.”

The T-cells do not respond properly, and the virus can spread.

Graham says this might explain why scientists have so far been unsuccessful in developing an AIDS vaccine. Many candidate vaccines attempt to bolster the T-cells, which have been weakened by what the virus does to the pDC cells.

Graham, along with his colleagues at several European universities, found a way to disable HIV’s cholesterol membrane so it cannot corrupt the first-responder cells, clearing the way for T-cells to fight the HIV infection, or pathogen, more effectively.

“The immune system now treated it more like a regular pathogen that you would encounter, and we would have normal immune responses that would result in protection," said Graham.

So far, research has been conducted only in the laboratory. But Graham says he hopes studies in animals and humans will eventually lead to an AIDS vaccine.

Amazing news

[Jordan.]

-doesn't understand a word of that-

But

[Jords]

Thats brilliant

[Jords]

It sounds so simple though, like why didnt we realise it needed cholesterol before?

[Ramsay]

Nice one
Now we just gotta find a way to get rid of Cancer

[Patrick]

Originally Posted by Karl

Nice one
Now we just gotta find a way to get rid of Cancer

I'm sure we're on the verge of a cure soon.

[Doogle]

But I agree it sounds like something they could've worked out before

[Ninastar]

My teacher is going to have a happy meltdown

[Patrick]

Absolutely fantastic.

[Benjamin]

That is a great scientific breakthrough.

[Mystic Mock]

Fantastic news,now just Cancer and Alzhimers to go.

[Glenn.]

I think if they have a way of curing AIDS then I think there is hope of a cure for Cancer. This is great news, for the millions of people that suffer with the disease.

[Ninastar]

omg the specialist is from where I lived in america

[Jords]

There will an easier cure for cancer, its sadly just finding it

[Patrick]

Originally Posted by Jords

There will an easier cure for cancer, its sadly just finding it

What if it turns out to be something like 'Eat loads of onions' or something really simple and it was there all along.
I would actually cry.

[MTVN]

Hmm I'm sceptical

[Patrick]

No Pun Intended there.